Antihyperglycemic Activity of Trianthema Portulacastrum Plant in Streptozotocin Induced Diabetic Rats
نویسندگان
چکیده
The objective of the present study was to evaluate the antihyperglycemic activity of methanolic extract of Trianthema portulacastrum whole plant in streptozotocin-induced diabetic rats. The STZ induced diabetic rats are divided into four groups of six animals each. Group I served as diabetic control, Group II diabetic rats were treated with a standard oral hypoglycaemic agent, glibenclamide (1mg/kg) while Group III and IV diabetic rats received 100 mg/kg and 200 mg/kg suspension of methanolic extract of Trianthema portulacastrum. The methanolic extract (METP) produced a significant antihyperglycemic effect (p<0.05) after 1 hr following administration and this antihyperglycemic effect was more pronounced after 4 hrs of treatment in streptozotocininduced diabetic rats. The findings of the present study suggest that the methanolic extract of Trianthema portulacastrum produced significant antihyperglycemic activity in STZ induced diabetic rat which is comparable to Glibenclamide (a standard oral hypoglycaemic agent).
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